ACell’s patented core technology, MatriStem UBM™ (Urinary Bladder Matrix), is the only commercially available form of urinary bladder matrix. UBM appears to facilitate the body’s naturally adaptive or accommodative immune response, which is conducive for wound healing and three-dimensional growth of various cell types.1 In the presence of UBM, in pre-clinical studies, the body has been observed to:

  • Angiogenesis1 and innervation2
  • Modulation of the inflammatory response1
  • Participation of autologous progenitor cells3,6
  • Resistance to infection5
  • Host deposition of functional, site-appropriate tissue4,6,7

  1. Daly KA, Liu S, Agrawal V, Brown BN, Johnson SA, Medberry CJ, Badylak SF†. Damage associated molecular patterns within xenogeneic biologic scaffolds and their effects on host remodeling. Biomaterials. 2012;33:91-101.
  2. Agrawal V, Brown BN, Beattie AJ, Gilbert TW*, Badylak SF†. Evidence of innervation following extracellular matrix scaffold-mediated remodelling of muscular tissues. Journal of Tissue Engineering and Regenerative Medicine. 2009;3:590-600.
  3. Agrawal V, Johnson SA, Reing J, Zhang L, Tottey S, Wang G, Hirschi KK, Braunhut S, Gudas LJ, Badylak SF†. Epimorphic regeneration approach to tissue replacement in adult mammals. Proceedings of the National Academy of Sciences of the United States of America. 2010;107:3351-3355.
  4. Sicari BM, Rubin JP, Dearth CL‡, Wolf MT, Ambrosio F, Boninger M, Turner NJ, Weber DJ, Simpson TW, Wyse A, Brown EH, Dziki JL, Fisher LE, Brown S, Badylak SF†. An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss. Science Translational Medicine. 2014;6:234ra258.
  5. Medberry CJ, Tottey S, Jiang H, Johnson SA, Badylak SF†. Resistance to infection of five different materials in a rat body wall model. The Journal of Surgical Research. 2012;173:38-44.
  6. Gilbert TW*, Nieponice A†, Spievack AR, Holcomb J, Gilbert S, Badylak SF†. Repair of the thoracic wall with an extracellular matrix scaffold in a canine model. The Journal of Surgical Research. 2008;147:61-67.
  7. Remlinger NT*, Gilbert TW*, Yoshida M, Guest BN, Hashizume R, Weaver ML, Wagner WR, Brown BN, Tobita K, Wearden PD. Urinary bladder matrix promotes site appropriate tissue formation following right ventricle outflow tract repair. Organogenesis. 2013;9:149-160.