Technology


ACell’s patented core technology, MatriStem UBM™ (Urinary Bladder Matrix), is the only commercially available form of urinary bladder matrix. UBM appears to facilitate the body’s naturally adaptive or accommodative immune response, which is conducive for wound healing and three-dimensional growth of various cell types.1 In the presence of UBM, in pre-clinical studies, the body has been observed to:

  • Angiogenesis1,2 and innervation2
  • Modulation of the inflammatory response1,4
  • Participation of autologous progenitor cells5
  • Resistance to infection6
  • Host deposition of functional, site-appropriate tissue2,5,7,8


  1. Brown BN, Londono R, Tottey S, Zhang L, Kukla KA, Wolf MT, Daly KA, Reing JE, Badylak SF†. Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials. Acta Biomaterialia. 2012; 8:978-987.
  2. Young DA*, Jackson N, Ronaghan CA†, Brathwaite CEM†, Gilbert TW*. Retrorectus repair of incisional ventral hernia with urinary bladder matrix reinforcement in a long-term porcine model. Regenerative Medicine. 2018; doi:10.2217/rme-2018-0023.
  3. Agrawal V, Brown BN, Beattie AJ, Gilbert TW*, Badylak SF†. Evidence of innervation following extracellular matrix scaffold-mediated remodelling of muscular tissues. Journal of Tissue Engineering and Regenerative Medicine. 2009; 3:590-600.
  4. Sadtler K, Sommerfeld SD, Wolf MT, Wang X, Majumdar S, Chung L, Kelkar DS, Pandley A, Elisseeff JH‡. Proteomic composition and immunomodulatory properties of urinary bladder matrix scaffolds in homeostatis and injury. Seminars in Immunology. 2017; http://dx.doi.org/ 10.1016/j.smim.2017.05.002.
  5. Sicari BM, Rubin JP, Dearth CL, Wolf MT, Ambrosio F, Boninger M, Turner NJ, Weber DJ, Simpson TW, Wyse
    A, Brown EH, Dziki JL, Fisher LE, Brown S, Badylak SF†. An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss. Science Translational Medicine. 2014;6(234):234ra258.
  6. Medberry CJ, Tottey S, Jiang H, Johnson SA, Badylak SF†. Resistance to infection of five different materials in a rat body wall model. The Journal of Surgical Research. 2012; 173:38-44.
  7. Gilbert TW*, Nieponice A†, Spievack AR, Holcomb J, Gilbert S, Badylak SF†. Repair of the thoracic wall with an extracellular matrix scaffold in a canine model. The Journal of Surgical Research. 2008; 147:61-67.
  8. Riganti JM, Ciotola F, Amenabar A, Craiem D, Graf S, Badaloni A, Gilbert TW*, Nieponice A‡. Urinary bladder matrix scaffolds strengthen esophageal hiatus repair. Journal of Surgical Research. 2016; 204:344-50.