Scientific Validation
Urinary Bladder Matrix (UBM) has been researched extensively and its characteristics have been shown to be beneficial for various wound and surgical applications.
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Trauma & reconstructive surgery
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Abdominal wall repair
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Urology
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Advanced wound care
The following is a non-exhaustive list of published and peer-reviewed scientific articles involving Urinary Bladder Matrix (UBM). This information is for educational purposes only.
Clinical Studies |
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Long-term clinical, radiological, and histological follow-up after complex ventral incisional hernia repair using urinary bladder matrix graft reinforcement: a retrospective cohort study. Hernia. 2018; doi: 10.1007/s10029-018-1830-0. Sasse KC†, Lambin JH, Gevorkian J, Elliott C, Afshar R, Gardner A, Mehta A, Lambin R, Peraza L. |
Paraesophageal hiatal hernia repair with urinary bBladder matrix graft. Journal of the Society of Laparoendoscopic Surgeons. 2018; 22(2). doi: 10.4293/JSLS.2017.00100. Howell RS, Fazzari M, Petrone P, Barkan A, Hall K, Servide MJ, Anduaga MF, Brathwaite CEM†. |
Urinary bladder matrix reinforcement for laparoscopic hiatal hernia repair. Journal of the Society of Laparoendoscopic Surgeons. 2018; 22(2). doi: 10.4293/ JSLS.2017.00060. Zografakis J†, Johnston G, Haas J, Berbiglia L, Bedford T, Spear J, Dan A, Pozsgay M. |
Extracellular matrix applications in the treatment of open fractures with complex wounds and large soft tissue defects. Journal of Orthopaedic Trauma. 2018; 32: e76-e80. Fokin AA, Puente I, Hus N†, Rodriguez E, Weisz RD. |
Massive localized lymphedema: Wound reconstruction with extracellular matrix. Wounds. 2017; 29(4): E22-E27. Scantling D, Pontell ME, Pedevillano L, Jacob TC, Guilday R. |
Regenerative medicine for soft tissue coverage of the hand and upper extremity. Current Orthopaedic Practice. 2017; 29(2): 120-126. Lanier ST, Ruter DI, Valerio IL. |
Complicated mammoplasty and breast salvage with application of extracellular matrix. American Surgeon. 2017; 83:E243-E244. Swickard AL, Sciarretta JD. |
Porcine urinary bladder matrix for management of infected radiation mastectomy wound. Cureus. 2017; 9(7): e1451. DOI 10.7759/cureus.1451. Puckett Y, Pham T, McReynolds S, Ronaghan CA†. |
Laparoscopic rectopexy with urinary bladder xenograft reinforcement. Journal of the Society of Laparoendoscopic Surgeons. 2017; 21(1): doi: 10.4293/JSLS.2016.00106. Mehta A, Afshar R, Warner DL, Gardner A, Ackerman E, Brandt J, Sasse KC†. |
The use of acellular urinary bladder matrix as coverage for fasciocutaneous free flap donor sites: An alternative to traditional grafting procedures. Journal of Oral Maxillofacial Surgery. 2017; doi: 10.1016/j.joms.2017.03.011. Melville JC, Bennetts NA, Tijerina L, Shum JW. |
Diabetic foot ulcers treated with porcine urinary bladder extracellular matrix and total contact cast: Interim analysis of a randomized, Wounds. 2017; pii: WNDS20170227-1. Alvarez OM, Smith T, Gilbert TW*, Onumah NJ, Wendelken ME, Parker R, Markowitz L. |
Management of open lower extremity wounds with concomitant fracture using a porcine urinary bladder matrix. Wounds. 2016; 28(11): 342-349. Kraemer BA†, Geiger SE, Deigni OA, Watson JT. |
A comparative analysis of skin substitutes used in the management of diabetic foot ulcers. Journal of Wound Care; 25(Sup10):S8-S17. Martinson M, Martinson N. |
Management of open distal lower extremity wounds with exposed tendons using porcine urinary bladder matrix. Wounds. 2016; 28(9): 306-316. Geiger SE, Deigni OA, Watson JT, Kraemer BA†. |
An evaluation of tissue engineering approaches for management of neuropathic diabetic foot ulcers resistant to standard of care: An interim analysis. Journal of Wound Care. 2016; 25(Sup7):S18-S25. Frykberg RG, Cazzell SM, Arroyo-Rivera J, Tallis A, Reyzelmen AM, Saba F, Warren L, Stouch BC, Gilbert TW*. |
New innovations for deep partial-thickness burn treatment with ACell MatriStem Matrix. Advances in Wound Care. 2016; doi: 10.1089/wound.2015.0681. Kim JS, Kaminsky AJ, Summitt JB‡, Thayer WP‡. |
Use of scaffolding tissue biografts To bolster vesicourethral anastomosis during salvage robot-assisted prostatectomy reduces leak rates and catheter times. European Urology. 2016; doi: 10.1016/ j.eururo.2016.10.004. Ogaya-Pines G, Kadakia Y, Palayapalayam-Ganapathi H, Woodlief T, Jensen C, Syed J, Patal V. |
Hiatal hernia repair with novel biological graft reinforcement. Journal of the Society of Laparoendoscopic Surgeons. 2016; 20(2): doi: 10.4293/JSLS.2016.00016. Sasse KC†, Warner DL, Ackerman E, Brandt J. |
Parastomal hernia repair with urinary bladder matrix grafts: Case series with 2-year follow-up and discussion. International Journal of Case Reports and Images (IJCRI). 2016; 7(2):85-91. Sasse KC†, Warner DL, Ackerman E, Brandt J. |
Extracellular matrix scaffold in diaphragmatic crura reinforcement during laparoscopic repair of large hiatal hernia. Journal of Surgery & Transplantation Science. 2016; 4(1): 1018-21. Reznichenko AA. |
Different biologic grafts for diaphragmatic crura reinforcement during laparoscopic repair of large hiatal hernia: A 6-Year single surgeon experience. Journal of Medical Implants and Surgery. 2015; 1:101. doi:10.4172/jmis.1000101. Reznichenko AA. |
Acellular micronized extracellular matrix and occlusive dressings for open fingertip injuries. Plastic and Aesthetic Research. 2015; 2:282-3. Dreifuss SE, Wollstein R, Badylak SF†, Rubin PJ. |
The use of urinary bladder matrix in the treatment of trauma and combat casualty wound care. Regenerative Medicine. 2015; 10(5):611-622. Valerio IL, Campbell P, Sabino J, Dearth CD, Fleming M. |
Report of an unusually large, surgically excised squamous cell carcinoma successfully treated with porcine transitional epithelium. Journal of the American Academy of Dermatology. 2015; 1:200-2. Bacigalupi R, Khorasani H. |
Endoscopic deployment of MatriStem for treatment of a colorectal anastomotic leak. Case Reports from Society of Laparoendscopic Surgeons. 2015; doi: 10.4293/CRSLS.2014.00080. Iorio T, Blumberg. |
Esophageal Reinforcement with a Extracellular Scaffold During Total Gastrectomy for Gastric Cancer. Annals of Surgical Oncology. 2014; doi:10.1245/s10434-014-4125-4. Afaneh C, Abelson J, Schattner M, Janjigian YY, Ilson D, Yoon SS, Strong VE. |
The use of urinary bladder matrix in the treatment of complicated open wounds. Wounds. 2014; 26(7):189-196. Parcells AL, Abernathie B, Ramazi D. |
Application of the orthoplastic reconstructive ladder to preserve lower extremity amputation length. Annals of Plastic Surgery. 2014. Fleming ME, O'Daniel A, Bharmal H, Valerio I.a |
Regenerative medicine applications in combat casualty care. Regenerative Medicine. 2014;9:179-190. Fleming ME, Bharmal H, Valerio I. |
Accelerated healing of complex open pilonidal wounds using matristem extracellular matrix xenograft: Nine cases. Journal of Surgical Case Reports. 2013;4. Sasse KC†, Brandt J, Lim DC, Ackerman E. |
Complex wounds treated with matristem xenograft material: Case series and cost analysis. OA Surgery. 2013;1. Sasse KC†, Ackerman EM, Brandt JR. |
Urinary bladder matrix for the treatment of recalcitrant nonhealing radiation wounds. Advances in Skin & Wound Care. 2013;26:450-455. Rommer EA, Peric M, Wong A. |
Salvage of failed local and regional flaps with porcine urinary bladder extracellular matrix aided tissue regeneration. Case Reports in Otolaryngology. 2013;2013:917183. Kruper GJ, Vandegriend ZP, Lin HS, Zuliani GF. |
Porcine bladder extracellular matrix for closure of a large defect in a burn contracture release. Journal of Wound Care. 2012;21:454-456. Mitchell KB, Gallagher JJ. |
Porcine urinary bladder matrix: A retrospective study and establishment of protocol. Journal of Wound Care. 2012;21:476, 478-480, 482. Lecheminant J, Field C. |
Nasal resurfacing with xenographic bladder bioscaffold following excision of massive rhinophyma. Journal of Otology and Rhinology. 2012;1:3, 1-3. Vande Griend ZP, Zuliani GF. |
The clinical effectiveness in wound healing with extracellular matrix derived from porcine urinary bladder matrix: A case series on severe chronic wounds. The Journal of the American College of Certified Wound Specialists. 2010;2:55-59. Kimmel H, Rahn M, Gilbert TW*. |
Pre-Clinical Studies |
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Comparison of in vivo remodeling of urinary bladder matrix and acellular dermal matrix in an ovine model. Regenerative Medicine. 2018; doi: 10.2217/rme-2018-0091. Young DA*, McGilvray KC, Ehrhart N Gilbert TW*. |
Retrorectus repair of incisional ventral hernia with urinary bladder matrix reinforcement in a long-term porcine model. Regenerative Medicine. 2018; doi:10.2217/rme-2018-0023. Young DA*, Jackson N, Ronaghan CA†, Brathwaite CEM†, Gilbert TW*. |
Proteomic composition and immunomodulatory properties of urinary bladder matrix scaffolds in homeostatis and injury. Seminars in Immunology. 2017; http://dx.doi.org/ 10.1016/j.smim.2017.05.002. Sadtler K, Sommerfeld SD, Wolf MT, Wang X, Majumdar S, Chung L, Kelkar DS, Pandley A, Elisseeff JH‡. |
Mechanical strength vs. degradation of a biologically-derived surgical mesh over time in a rodent full thickness abdominal wall defect. Biomaterials. 2016; 108:81-90. Costa A, Naranjo JD, Turner NJ, Swinehart IT, Kolich BD, Shaffiey SA, Londono R, Keane TJ, Reing JE, Johnson SA, Badylak SF†. |
Solubilized extracellular matrix bioscaffolds derived from diverse source tissues differentially influence macrophage phenotype. Journal of Biomedical Materials Research A. 2016; doi: 10.1002/jbm.a.35894. Dziki JL, Wang DS, Pineda C, Sicari BM, Rausch T, Badylak SF†. |
Urinary bladder matrix scaffolds strengthen esophageal hiatus repair. Journal of Surgical Research. 2016; 204:344-50. Riganti JM, Ciotola F, Amenabar A, Craiem D, Graf S, Badaloni A, Gilbert TW*, Nieponice A‡. |
Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury. Acta Biomaterialia. 2015. http://dx.doi.org/10.1016/j.actbio.2015.11.043. Dearth CL, Slivka PF, Steward SA, Keane TJ, Tay JK, Londono R, Goh Q, Pizza FX, Badylak SF. |
In vitro evaluation of acellular porcine urinary bladder extracellular matrix – A potential scaffold in tissue engineered skin. Wound Medicine. 2015;10-11:9-16. Coakley DN, Shaikh FM, O’Sullivan K, Kavanagh EG, Grace PA, McGloughlin TM. |
Fractionation of an ECM hydrogel into structural and soluble components reveals distinctive roles in regulating macrophage behavior. Biomaterials Science. 2014; 2(10):1521-34. Slivka PF, Dearth CL, Keane TJ, Meng FW, Medberry CJ, Riggio RT, Reing JE, Badylak SF†. |
The effect of detergents on the basement membrane complex of a biologic scaffold material. Acta Biomaterialia. 2014;10:183-193. Faulk DM, Carruthers CA, Warner HJ, Kramer CR, Reing JE, Zhang L, D'Amore A, Badylak SF†. |
Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials. Acta Biomaterialia. 2012;8:978-987. Brown BN, Londono R, Tottey S, Zhang L, Kukla KA, Wolf MT, Daly KA, Reing JE, Badylak SF†. |
One and four layer acellular bladder matrix for fascial tissue reconstruction. Journal of Materials Science. Materials in Medicine. 2011;22:741-751. Eberli D, Atala A†, Yoo JJ. |
The surface molecular functionality of decellularized extracellular matrices. Biomaterials. 2011;32:137-143. Barnes CA, Brison J, Michel R, Brown BN, Castner DG, Badylak SF†, Ratner BD. |
Surface characterization of extracellular matrix scaffolds. Biomaterials. 2010;31:428-437. Brown BN, Barnes CA, Kasick RT, Michel R, Gilbert TW*, Beer-Stolz D, Castner DG, Ratner BD, Badylak SF†. |
Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component. Biomaterials. 2009;30:1482-1491. Brown BN, Valentin JE, Stewart-Akers AM, McCabe GP, Badylak SF†. |
Extracellular matrix as a biological scaffold material: Structure and function. Acta Biomaterialia. 2009;5:1-13. Badylak SF†, Freytes DO, Gilbert TW*. |
Quantification of DNA in biologic scaffold materials. Journal of Surgical Research. 2009; 152: 135-139. Gilbert TW*, Freund JM, Badylak SF†. |
Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrix. Biomaterials. 2008;29:4775-4782. Gilbert TW*, Wognum S, Joyce EM, Freytes DO, Sacks MS, Badylak SF†. |
Hydrated versus lyophilized forms of porcine extracellular matrix derived from the urinary bladder. Journal of Biomedical Materials Research. Part A. 2008;87:862-872. Freytes DO, Tullius RS, Valentin JE, Stewart-Akers AM, Badylak SF†. |
Uniaxial and biaxial properties of terminally sterilized porcine urinary bladder matrix scaffolds. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 2008;84:408-414. Freytes DO, Stoner RM, Badylak SF†. |
Reinforcement of esophageal anastomoses with an extracellular matrix scaffold in a canine model. The Annals of Thoracic Surgery. 2006;82:2050-2058. Nieponice A†, Gilbert TW*, Badylak SF†. |
Decellularization of tissues and organs. Biomaterials. 2006;27:3675-3683. Gilbert TW*, Sellaro TL, Badylak SF†. |
Effect of storage upon material properties of lyophilized porcine extracellular matrix derived from the urinary bladder. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 2006;78:327-333. Freytes DO, Tullius RS*, Badylak SF†. |
The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Engineering. 2006;12:519-526. Brown B, Lindberg K, Reing J, Stolz DB, Badylak SF†. |
Production and characterization of ECM powder: Implications for tissue engineering applications. Biomaterials. 2005;26:1431-1435. Gilbert TW*, Stolz DB, Biancaniello F, Simmons-Byrd A, Badylak SF†. |
Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test. Biomaterials. 2005;26:5518-5531. Freytes DO, Rundell AE, Vande Geest J, Vorp DA, Webster TJ, Badylak SF†. |
Biaxial strength of multilaminated extracellular matrix scaffolds. Biomaterials. 2004;25:2353-2361. Freytes DO, Badylak SF†, Webster TJ, Geddes LA, Rundell AE. |
Retention of endothelial cell adherence to porcine-derived extracellular matrix after disinfection and sterilization. Tissue Engineering. 2002;8:225-234++=+ Hodde JP, Record RD, Tullius RS*, Badylak SF†. |
† Consultant
‡ ACell Sponsored Research Agreement
* ACell Employee