PUBLICATIONS


Scientific Validation

Urinary Bladder Matrix (UBM) has been researched extensively and its characteristics have has been shown to be beneficial for various wound and surgical applications.

  • Trauma & reconstructive surgery

  • Esophageal reconstruction

  • Abdominal wall repair

  • Urology

  • Pelvic floor reconstruction

  • Advanced wound care


The following is a non-exhaustive list of published and peer-reviewed scientific articles involving Urinary Bladder Matrix (UBM). This information is for educational purposes only.

Clinical Studies

Management of open lower extremity wounds with concomitant fracture using a porcine urinary bladder matrix.


Wounds. 2016; 28(11): 342-349. Kraemer BA†, Geiger SE, Deigni OA, Watson JT.

A comparative analysis of skin substitutes used in the management of diabetic foot ulcers.


Journal of Wound Care; 25(Sup10):S8-S17. Martinson M, Martinson N.

Decellularized matrix and supplemental at grafting leads to regeneration following traumatic fingertip amputation.


Plastic & Reconstructive Surgery Global Open 2016;4:e1094; doi: 10.1097/GOX.0000000000001094. Sivak WN, Ruane EJ, Hausman SJ, Rubin JP, Spiess AM.

Management of open distal lower extremity wounds with exposed tendons using porcine urinary bladder matrix.


Wounds. 2016; 28(9): 306-316. Geiger SE, Deigni OA, Watson JT, Kraemer BA†.

An evaluation of tissue engineering approaches for management of neuropathic diabetic foot ulcers resistant to standard of care: An interim analysis.


Journal of Wound Care. 2016; 25(Sup7):S18-S25. Frykberg RG, Cazzell SM, Arroyo-Rivera J, Tallis A, Reyzelmen AM, Saba F, Warren L, Stouch BC, Gilbert TW*.

An acellular biologic scaffold treatment for volumetric muscle loss: results of a 13-patient cohort study.


Nature Regenerative Medicine. 2016; 1, 16008; doi:10.1038/npjregenmed.2016.8. Dziki J, Badylak S†, Yabroudi M, Sicari B, Ambrosio F, Stearns K, Turner N, Wyse A, Boninger ML, Brown EHP, Rubin JP.

Hiatal hernia repair with novel biological graft reinforcement.


Journal of the Society of Laparoendoscopic Surgeons. 2016; 20(2): doi: 10.4293/JSLS.2016.00016. Sasse KC†, Warner DL, Ackerman E, Brandt J.

Novel use of porcine urinary bladder matrix for pediatric pilonidal wound care: preliminary experience.


Pediatric Surgery International. 2016; doi: 10.1007/s00383-016-3915-0. Dorman RM, Bass KD.

Novel treatment of a septal ulceration using an extracellular matrix scaffold (septal ulceration treatment using ECM).


American Journal of Otolaryngology. 2016; 37(3):195-8. Liu YC, Chhabra N, Houser SM.

Right atrial tumor resection and reconstruction with use of an acellular porcine bladder membrane.


Texas Heart Institute Journal. 2016; 43(2):175-7. Abu Saleh WK, Al Jabbari O, Ramlawi B, Bruckner BA, Loebe M, Reardon MJ.

A rare case of left atrial hemangioma: Surgical resection and reconstruction.


Methodist Debakey Cardiovascular Journal. 2016; 12(1):51-4. Abu Saleh WK, Al Jabbari O, Bruckner BA, Reardon MJ.

New innovations for deep partial-thickness burn treatment with ACell MatriStem Matrix.


Advances in Wound Care. 2016; doi: 10.1089/wound.2015.0681. Kim JS, Kaminsky AJ, Summitt JB‡, Thayer WP‡.

Parastomal hernia repair with urinary bladder matrix grafts: Case series with 2-year follow-up and discussion.


International Journal of Case Reports and Images (IJCRI). 2016; 7(2):85-91. Sasse KC†, Warner DL, Ackerman E, Brandt J.

Extracellular matrix scaffold in diaphragmatic crura reinforcement during laparoscopic repair of large hiatal hernia.


Journal of Surgery & Transplantation Science. 2016; 4(1): 1018-21. Reznichenko AA.

Percutaneous bioorganic sealing of duodenal fistulas:Case report and review of biological sealants with potential use in interventional radiology.


Cardiovascular and Interventional Radiology. 2015; 38:1036-42. Wadhwa V, Leeper WR, Tamrazi A.

Enterocutaneous fistula: Successful treatment of two cases with urinary bladder matrix xenograft.


International Journal of Case Reports and Images. 2015; 6(12):730-33. Sasse KC†, Warner DL.

Different biologic grafts for diaphragmatic crura reinforcement during laparoscopic repair of large hiatal hernia: A 6-Year single surgeon experience.


Journal of Medical Implants and Surgery. 2015; 1:101. doi:10.4172/jmis.1000101. Reznichenko AA.

Acellular micronized extracellular matrix and occlusive dressings for open fingertip injuries.


Plastic and Aesthetic Research. 2015; 2:282-3. Dreifuss SE, Wollstein R, Badylak SF†, Rubin PJ.

The use of urinary bladder matrix in the treatment of trauma and combat casualty wound care.


Regenerative Medicine. 2015; 10(5):611-622. Valerio IL, Campbell P, Sabino J, Dearth CD, Fleming M.

The use of biologic scaffolds in the treatment of chronic nonhealing wounds.


Advances in Wound Care. 2015; 4(8): 490-500. Turner NJ, Badylak SF.

Endoscopic deployment of MatriStem for treatment of a colorectal anastomotic leak.


Case Reports from Society of Laparoendscopic Surgeons. 2015; doi: 10.4293/CRSLS.2014.00080. Iorio T, Blumberg.

Hair restoration surgery: challenges and solutions.


Clinical, Cosmetic, and Investigational Dermatology. 2015; 8:361-370. Rose PT.

Successful three stage repair of a large congenital abdominal region defect.


Journal of Pediatric Surgery Case Reports. 2015;230-33. Agrawal V, Almond PS, Reyna R, Emran MA.

Short-term results of treating primary and recurrent anal fistulas with a novel extracellular matrix derived from porcine urinary bladder.


American Surgeon. 2015; 81(5):498-502. Iorio T, Blumberg D.

Esophageal Reinforcement with a Extracellular Scaffold During Total Gastrectomy for Gastric Cancer.


Annals of Surgical Oncology. 2014; doi:10.1245/s10434-014-4125-4. Afaneh C, Abelson J, Schattner M, Janjigian YY, Ilson D, Yoon SS, Strong VE.

The use of urinary bladder matrix in the treatment of complicated open wounds.


Wounds. 2014; 26(7):189-196. Parcells AL, Abernathie B, Ramazi D.

Targeted rehabilitation after extracellular matrix scaffold transplantation for the treatment of volumetric muscle loss.


American Journal of Physical Medicine & Rehabilitation. 2014; 93(Suppl):S79-S87. Gentile NE, Stearns KM, Brown EHP, Rubin JP, Boninger ML, Dearth CL, Ambrosio F, Badylak SF†.

An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss.


Science Translational Medicine. 2014;6:234ra258. Sicari BM, Rubin JP, Dearth CL‡, Wolf MT, Ambrosio F, Boninger M, Turner NJ, Weber DJ, Simpson TW, Wyse A, Brown EH, Dziki JL, Fisher LE, Brown S, Badylak SF†.

Patch esophagoplasty: Esophageal reconstruction using biologic scaffolds.


Annals of Thoracic Surgery. 2014;97:283-288. Nieponice A†, Ciotola FF, Nachman F, Jobe BA, Hoppo T, Londono R, Badylak S†, Badaloni AE.

Application of the orthoplastic reconstructive ladder to preserve lower extremity amputation length.


Annals of Plastic Surgery. 2014. Fleming ME, O'Daniel A, Bharmal H, Valerio I.

Regenerative medicine applications in combat casualty care.


Regenerative Medicine. 2014;9:179-190. Fleming ME, Bharmal H, Valerio I.

Septal perforation repair without intraoperative mucosal closure.


The Laryngoscope. 2014;124:1112-1117. Flavill E, Gilmore JE.

Accelerated healing of complex open pilonidal wounds using matristem extracellular matrix xenograft: Nine cases.


Journal of Surgical Case Reports. 2013;4. Sasse KC†, Brandt J, Lim DC, Ackerman E.

Complex wounds treated with matristem xenograft material: Case series and cost analysis.


OA Surgery. 2013;1. Sasse KC†, Ackerman EM, Brandt JR.

Urinary bladder matrix for the treatment of recalcitrant nonhealing radiation wounds.


Advances in Skin & Wound Care. 2013;26:450-455. Rommer EA, Peric M, Wong A.

Salvage of failed local and regional flaps with porcine urinary bladder extracellular matrix aided tissue regeneration.


Case Reports in Otolaryngology. 2013;2013:917183. Kruper GJ, Vandegriend ZP, Lin HS, Zuliani GF.

Hair transplant and local anesthetics.


Clinical Plastic Surgery. 2013;40:615-25. Lam SM.

Porcine bladder extracellular matrix for closure of a large defect in a burn contracture release.


Journal of Wound Care. 2012;21:454-456. Mitchell KB, Gallagher JJ.

Porcine urinary bladder matrix: A retrospective study and establishment of protocol.


Journal of Wound Care. 2012;21:476, 478-480, 482. Lecheminant J, Field C.

Nasal resurfacing with xenographic bladder bioscaffold following excision of massive rhinophyma.


Journal of Otology and Rhinology. 2012;1:3, 1-3. Vande Griend ZP, Zuliani GF.

Regenerative materials that facilitate wound healing.


Clinical Plastic Surgery. 2012; 39:249-267. Mulder G, Wallin K, Tenenhaus M.

The clinical effectiveness in wound healing with extracellular matrix derived from porcine urinary bladder matrix: A case series on severe chronic wounds.


The Journal of the American College of Certified Wound Specialists. 2010;2:55-59. Kimmel H, Rahn M, Gilbert TW*.

Pre-Clinical Studies

Urinary bladder matrix scaffolds strengthen esophageal hiatus repair.


Journal of Surgical Research. 2016; 204:344-50. Riganti JM, Ciotola F, Amenabar A, Craiem D, Graf S, Badaloni A, Gilbert TW*, Nieponice A‡.

Matrix-bound nanovesicles within ECM bioscaffolds.


Science Advances. 2016; 2:e1600502. Huleihel L, Hussey GS, Naranjo JD, Zhang L, Dziki JL, Turner NJ, Stolz DB, Badylak SF†.

Injectable extracellular matrix hydrogels as scaffolds for spinal cord injury repair.


Tissue Engineering: Part A. 2016; 22(3&4): 306-17. Tukmachev D, Forostyak S, Koci Z, Zaviskova K, Vackova I, Vyborny K, Sandvig I, Sandvig A, Medberry CJ, Badylak SF†, Sykova E, Kubinova S.

Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury.


Acta Biomaterialia. 2015. http://dx.doi.org/10.1016/j.actbio.2015.11.043. Dearth CL, Slivka PF, Steward SA, Keane TJ, Tay JK, Londono R, Goh Q, Pizza FX, Badylak SF.

Acetylated bacterial cellulose coated with urinary bladder matrix as a substrate for retinal pigment epithelium.


Colloids and Surfaces. B, Biointerfaces. 2016; 139:1-9. Gonçalves S, Rodrigues IP, Padrão J, Silva JP, Sencadas V, Lanceros-Mendez S, Girão H, Gama FM, Dourado F, Rodrigues LR.

In vitro evaluation of acellular porcine urinary bladder extracellular matrix – A potential scaffold in tissue engineered skin.


Wound Medicine. 2015;10-11:9-16. Coakley DN, Shaikh FM, O’Sullivan K, Kavanagh EG, Grace PA, McGloughlin TM.

Concentration-dependent rheological properties of ECM hydrogel for intracerebral delivery to a stroke cavity.


Acta Biomaterialia. 2015; 27:116-30. Massensini AR, Ghuman H, Saldin LT, Medberry CJ, Keane TJ, Nicholls FJ, Velankar SS, Badylak SF, Modo M.

An acellular biologic scaffold does not regenerate appreciable de novo muscle tissue in rat models of volumetric muscle loss injury.


Biomaterials. 2015; 67:393-407. Aurora A, Roe JL, Corona BT, Walters TJ‡.

Solubilized extracellular matrix from brain and urinary bladder elicits distinct functional and phenotypic responses in macrophages.


Biomaterials. 2015;46:131-40. Meng FW, Slivka PF, Dearth CL, Badylak SF†.

Biomimetic Randall's plaque as an in vitro model system for studying the role of acidic biopolymers in idiopathic stone formation.


Urolithiasis. 2015;43 Suppl 1:77-92. Chidambaram A, Rodriguez D, Khan S, Gower L.

Fractionation of an ECM hydrogel into structural and soluble components reveals distinctive roles in regulating macrophage behavior.


Biomaterials Science. 2014; 2(10):1521-34. Slivka PF, Dearth CL, Keane TJ, Meng FW, Medberry CJ, Riggio RT, Reing JE, Badylak SF†.

In vivo assessment of a biological occlude for NOTES gastrotomy closure.


Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 2014; doi:10.1097/SLE. 0b013e3182a1c31b. Sanz AF, Hoppo T, Witteman BP, Brown BN, Gilbert TW*, Badylak SF†, Jobe BA, Nieponice A†.

Macrophage polarization in response to ECM coated polypropylene mesh.


Biomaterials. 2014;35:6838-6849. Wolf MT, Dearth CL‡, Ranallo CA, LoPresti ST, Carey LE, Daly KA, Brown BN, Badylak SF†.

Porcine urinary bladder extracellular matrix activates skeletal myogenesis in mouse muscle cryoinjury.


Journal of Regenerative Medicine and Tissue Engineering. 2014. Song J, Hornsby P, Stanley M, AbdelFattah KR, Wolf SE.

Glottic regeneration with a tissue-engineering technique, using acellular extracellular matrix scaffold in a canine model.


Journal of Tissue Engineering and Regenerative Medicine. 2014. Kitamura M, Hirano S, Kanemaru SI, Kitani Y, Ohno S, Kojima T, Nakamura T, Ito J, Rosen CA, Gilbert TW*.

The effect of detergents on the basement membrane complex of a biologic scaffold material.


Acta Biomaterialia. 2014;10:183-193. Faulk DM, Carruthers CA, Warner HJ, Kramer CR, Reing JE, Zhang L, D'Amore A, Badylak SF†.

On the potential of hydrated storage for naturally derived ECMs and associated effects on mechanical and cellular performance.


Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 2014;102:89-97. Davis LM, Callanan A, Carroll GT, Doyle BJ, Walsh MT, McGloughlin TM.

Effects of biologic scaffolds on human stem cells and implications for CNS tissue engineering.


Tissue Engineering. Part A. 2014;20:313-323. Crapo PM, Tottey S, Slivka PF, Badylak SF†.

Development of a rotational cell-seeding system for tubularized extracellular matrix (ECM) scaffolds in vascular surgery.


Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 2014;102:781-788. Callanan A, Davis NF, McGloughlin TM, Walsh MT.

The effects of stent interaction on porcine urinary bladder matrix employed as stent-graft materials.


Journal of Biomechanics. 2014;47:1885-1893. Callanan A, Davis NF, McGloughlin TM, Walsh MT.

Comparison of polypropylene mesh and porcine-derived, cross-linked urinary bladder matrix materials implanted in the rabbit vagina and abdomen.


International Urogynecology Journal. 2014; 25(5):683-9. Fan X, Wang Y, Yang Y, Xu H.

Commercially available biological mesh does not prevent stricture after esophageal mucosectomy.


Endoscopy. 2014;46:144-148. Schomisch SJ‡, Yu L, Wu Y, Pauli EM, Cipriano C, Chak A, Lash RH, Ponsky JL, Marks JM.

Effect of an inductive hydrogel composed of urinary bladder matrix upon functional recovery following traumatic brain injury.


Tissue Engineering. Part A. 2013;19:1909-1918. Zhang L, Zhang F, Weng Z, Brown BN, Yan H, Ma XM, Vosler PS, Badylak SF†, Dixon CE, Cui XT, Chen J.

Neurorestorative effect of urinary bladder matrix-mediated neural stem cell transplantation following traumatic brain injury in rats.


CNS & Neurological Disorders Drug Targets. 2013;12:413-425. Wang JY, Liou AK, Ren ZH, Zhang L, Brown BN, Cui XT, Badylak SF†, Cai YN, Guan YQ, Leak RK, Chen J, Ji X, Chen L.

Urinary bladder matrix promotes site appropriate tissue formation following right ventricle outflow tract repair.


Organogenesis. 2013;9:149-160 Remlinger NT*, Gilbert TW*, Yoshida M, Guest BN, Hashizume R, Weaver ML, Wagner WR, Brown BN, Tobita K, Wearden PD.

Bone marrow-derived cells participate in the long-term remodeling in a mouse model of esophageal reconstruction.


Journal of Surgical Research. 2013;182:e1-7. Nieponice A†, Gilbert TW*, Johnson SA, Turner NJ, Badylak SF†.

Hydrogels derived from central nervous system extracellular matrix.


Biomaterials. 2013;34:1033-1040. Medberry CJ, Crapo PM, Siu BF, Carruthers CA, Wolf MT, Nagarkar SP, Agrawal V, Jones KE, Kelly J, Johnson SA, Velankar SS, Watkins SC, Modo M, Badylak SF†.

Cell-seeded extracellular matrices for bladder reconstruction: An ex vivo comparative study of their biomechanical properties.


The International Journal of Artificial Organs. 2013;36:251-258. Davis NF, Mooney R, Piterina AV, Callanan A, Flood HD, McGloughlin TM.

Evaluation of xenogenic extracellular matrices as adjuvant scaffolds for the treatment of stress urinary incontinence.


International Urogynecology Journal. 2013;24:2105-2110. Davis NF, Coakley DN, Callanan A, Flood HD, McGloughlin TM.

Cardiac tissue development for delivery of embryonic stem cell-derived endothelial and cardiac cells in natural matrices.


Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 2012;100:2060-2072. Turner WS, Wang X, Johnson S, Medberry C, Mendez J, Badylak SF†, McCord MG, McCloskey KE.

Human mesenchymal stem cells seeded on extracellular matrix-scaffold: Viability and osteogenic potential.


Journal of Cellular Physiology. 2012;227:857-866. Penolazzi L, Mazzitelli S, Vecchiatini R, Torreggiani E, Lambertini E, Johnson S, Badylak SF†, Piva R, Nastruzzi C.

Resistance to infection of five different materials in a rat body wall model.


The Journal of Surgical Research. 2012;173:38-44. Medberry CJ, Tottey S, Jiang H, Johnson SA, Badylak SF†.

A comprehensive protein expression profile of extracellular matrix biomaterial derived from porcine urinary bladder.


Regenerative Medicine. 2012;7:159-166. Mar?al H, Ahmed T, Badylak SF†, Tottey S, Foster LJ.

Porcine urinary bladder matrix-polypropylene mesh: A novel scaffold material reduces immunorejection in rat pelvic surgery.


International Urogynecology Journal. 2012;23:1271-1278. Liu L, Deng L, Wang Y, Ge L, Chen Y, Liang Z.

Damage associated molecular patterns within xenogeneic biologic scaffolds and their effects on host remodeling.


Biomaterials. 2012;33:91-101. Daly KA, Liu S, Agrawal V, Brown BN, Johnson SA, Medberry CJ, Badylak SF†.

Biologic scaffolds composed of central nervous system extracellular matrix.


Biomaterials. 2012;33:3539-3547. Crapo PM, Medberry CJ, Reing JE, Tottey S, van der Merwe Y, Jones KE, Badylak SF†.

Mechanical characterisation of unidirectional and cross-directional multilayered urinary bladder matrix (UBM) scaffolds.


Medical Engineering & Physics. 2012;34:1368-1374. Callanan A, Davis NF, Walsh MT, McGloughlin TM.

Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials.


Acta Biomaterialia. 2012;8:978-987. Brown BN, Londono R, Tottey S, Zhang L, Kukla KA, Wolf MT, Daly KA, Reing JE, Badylak SF†.

Inductive, scaffold-based, regenerative medicine approach to reconstruction of the temporomandibular joint disk.


Journal of Oral and Maxillofacial Surgery. 2012;70:2656-2668. Brown BN, Chung WL, Almarza AJ, Pavlick MD, Reppas SN, Ochs MW, Russell AJ, Badylak SF†.

Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation.


Tissue Engineering. Part A. 2012;18:1454-1463. Agrawal V, Siu BF, Chao H, Hirschi KK, Raborn E, Johnson SA, Tottey S, Hurley KB, Medberry CJ, Badylak SF†.

Sensing and modulation of invadopodia across a wide range of rigidities.


Biophysical Journal. 2011;100:573-582. Parekh A, Ruppender NS, Branch KM, Sewell-Loftin MK, Lin J, Boyer PD, Candiello JE, Merryman WD, Guelcher SA, Weaver AM.

Production and characterization of engineered alginate-based microparticles containing ECM powder for cell/tissue engineering applications.


Acta Biomaterialia. 2011;7:1050-1062. Mazzitelli S, Luca G, Mancuso F, Calvitti M, Calafiore R, Nastruzzi C, Johnson S, Badylak SF.

Extracellular matrix powder protects against bleomycin-induced pulmonary fibrosis.


Tissue Engineering. Part A. 2011;17:2795-2804. Manni ML, Czajka CA, Oury TD, Gilbert TW*.

Evaluation of the biocompatibility and mechanical properties of xenogeneic (porcine) extracellular matrix (ECM) scaffold for pelvic reconstruction.


International Urogynecology Journal. 2011;22:221-227. Liu L, Li D, Wang Y, Xu H, Ge L, Liang Z.

Alpha1,3-galactosyltransferase knockout does not alter the properties of porcine extracellular matrix bioscaffolds.


Acta Biomaterialia. 2011;7:1719-1727. Liang R, Fisher M, Yang G, Hall C, Woo SL-Y.

Cultured keratinocytes on urinary bladder matrix scaffolds increase angiogenesis and help in rapid healing of wounds.


Advances in Skin & Wound Care. 2011;24:268-273. Eweida A, Saad M, Gabr E, Marei M, Khalil MR.

One and four layer acellular bladder matrix for fascial tissue reconstruction.


Journal of Materials Science. Materials in Medicine. 2011;22:741-751. Eberli D, Atala A†, Yoo JJ.

Construction and evaluation of urinary bladder bioreactor for urologic tissue-engineering purposes.


Urology. 2011;78:954-960. Davis NF, Mooney R, Piterina AV, Callanan A, McGuire BB, Flood HD, McGloughlin TM.

Augmentation cystoplasty and extracellular matrix scaffolds: An ex vivo comparative study with autogenous detubularised ileum.


PloS One. 2011;6:e20323. Davis NF, Mooney R, Callanan A, Flood HD, McGloughlin TM.

Porcine extracellular matrix scaffolds in reconstructive urology: An ex vivo comparative study of their biomechanical properties.


Journal of the Mechanical Behavior of Biomedical Materials. 2011;4:375-382. Davis NF, Callanan A, McGuire BB, Mooney R, Flood HD, McGloughlin TM.

Evaluation of viability and proliferative activity of human urothelial cells cultured onto xenogenic tissue-engineered extracellular matrices.


Urology. 2011;77:1007 e1001-1007. Davis NF, Callanan A, McGuire BB, Flood HD, McGloughlin TM.

An overview of tissue and whole organ decellularization processes.


Biomaterials. 2011;32:3233-3243. Crapo PM, Gilbert TW, Badylak SF.

Extracellular matrix as an inductive template for temporomandibular joint meniscus reconstruction: A pilot study.


Journal of Oral and Maxillofacial Surgery. 2011;69:e488-505. Brown BN, Chung WL, Pavlick M, Reppas S, Ochs MW, Russell AJ, Badylak SF†.

The surface molecular functionality of decellularized extracellular matrices.


Biomaterials. 2011;32:137-143. Barnes CA, Brison J, Michel R, Brown BN, Castner DG, Badylak SF†, Ratner BD.

Recruitment of progenitor cells by an extracellular matrix cryptic peptide in a mouse model of digit amputation.


Tissue Engineering. Part A. 2011;17:2435-2443. Agrawal V, Tottey S, Johnson SA, Freund JM, Siu BF, Badylak SF†.

Microtopographical effects of natural scaffolding on cardiomyocyte function and arrhythmogenesis.


Acta Biomaterialia. 2010;6:3029-3034. Shah U, Bien H, Entcheva E.

Biodome regenerative sleeve for biochemical and biophysical stimulation of tissue regeneration.


Medical Engineering & Physics. 2010;32:1065-1073. Hechavarria D, Dewilde A, Braunhut S, Levin M, Kaplan DL.

Surface characterization of extracellular matrix scaffolds.


Biomaterials. 2010;31:428-437. Brown BN, Barnes CA, Kasick RT, Michel R, Gilbert TW*, Beer-Stolz D, Castner DG, Ratner BD, Badylak SF†.

Constructive remodeling of biologic scaffolds is dependent on early exposure to physiologic bladder filling in a canine partial cystectomy model.


The Journal of Surgical Research. 2010;161:217-225. Boruch AV, Nieponice A†, Qureshi IR, Gilbert TW*, Badylak SF†.

Epimorphic regeneration approach to tissue replacement in adult mammals.


Proceedings of the National Academy of Sciences of the United States of America. 2010;107:3351-3355. Agrawal V, Johnson SA, Reing J, Zhang L, Tottey S, Wang G, Hirschi KK, Braunhut S, Gudas LJ, Badylak SF†.

Oxygen diffusivity of biologic and synthetic scaffold materials for tissue engineering.


Journal of Biomedical Materials Research. Part A. 2009;91:1010-1017. Valentin JE, Freytes DO, Grasman JM, Pesyna C, Freund J, Gilbert TW*, Badylak SF†.

Degradation products of extracellular matrix affect cell migration and proliferation.


Tissue Engineering. Part A. 2009;15:605-614. Reing JE, Zhang L, Myers-Irvin J, Cordero KE, Freytes DO, Heber-Katz E, Bedelbaeva K, McIntosh D, Dewilde A, Braunhut SJ, Badylak SF†.

Extracellular matrices as advanced scaffolds for vascular tissue engineering.


Bio-medical Materials and Engineering. 2009;19:333-348. Piterina AV, Callanan A, Davis L, Meaney C, Walsh M, McGloughlin TM.

Repair of the tympanic membrane with urinary bladder matrix.


The Laryngoscope. 2009;119:1206-1213. Parekh A, Mantle B, Banks J, Swarts JD, Badylak SF†, Dohar JE, Hebda PA‡.

An extracellular matrix scaffold for esophageal stricture prevention after circumferential EMR.


Gastrointestinal Endoscopy. 2009;69:289-296. Nieponice A†, McGrath K, Qureshi I, Beckman EJ, Luketich JD, Gilbert TW*, Badylak SF†.

Increased myocyte content and mechanical function within a tissue-engineered myocardial patch following implantation.


Tissue Engineering. Part A. 2009;15:2189-2201. Kelly DJ, Rosen AB, Schuldt AJ, Kochupura PV, Doronin SV, Potapova IA, Azeloglu EU, Badylak SF†, Brink PR, Cohen IS, Gaudette GR.

Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component.


Biomaterials. 2009;30:1482-1491. Brown BN, Valentin JE, Stewart-Akers AM, McCabe GP, Badylak SF†.

Chemoattraction of progenitor cells by remodeling extracellular matrix scaffolds.


Tissue Engineering. Part A. 2009;15:1119-1125. Beattie AJ, Gilbert TW*, Guyot JP, Yates AJ, Badylak SF†.

Extracellular matrix as a biological scaffold material: Structure and function.


Acta Biomaterialia. 2009;5:1-13. Badylak SF†, Freytes DO, Gilbert TW*.

Quantification of DNA in biologic scaffold materials.


Journal of Surgical Research. 2009; 152: 135-139. Gilbert TW*, Freund JM, Badylak SF†.

Evidence of innervation following extracellular matrix scaffold-mediated remodelling of muscular tissues.


Journal of Tissue Engineering and Regenerative Medicine. 2009;3:590-600. Agrawal V, Brown BN, Beattie AJ, Gilbert TW*, Badylak SF†.

Hybrid nanofibrous scaffolds from electrospinning of a synthetic biodegradable elastomer and urinary bladder matrix.


Journal of Biomaterials Science. Polymer Edition. 2008;19:635-652. Stankus JJ, Freytes DO, Badylak SF†, Wagner WR.

Decellularization and sterilization of porcine urinary bladder matrix for tissue engineering in the lower urinary tract.


Regenerative Medicine. 2008;3:145-156. Rosario DJ, Reilly GC, Ali Salah E, Glover M, Bullock AJ, Macneil S.

A fusion protein of hepatocyte growth factor enhances reconstruction of myocardium in a cardiac patch derived from porcine urinary bladder matrix.


The Journal of Thoracic and Cardiovascular Surgery. 2008;136:1309-1317. Ota T, Gilbert TW*, Schwartzman D, McTiernan CF, Kitajima T, Ito Y, Sawa Y, Badylak SF†, Zenati MA.

Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrix.


Biomaterials. 2008;29:4775-4782. Gilbert TW*, Wognum S, Joyce EM, Freytes DO, Sacks MS, Badylak SF†.

Repair of the thoracic wall with an extracellular matrix scaffold in a canine model.


The Journal of Surgical Research. 2008;147:61-67. Gilbert TW*, Nieponice A†, Spievack AR, Holcomb J, Gilbert S, Badylak SF†.

Morphologic assessment of extracellular matrix scaffolds for patch tracheoplasty in a canine model.


The Annals of Thoracic Surgery. 2008;86:967-974. Gilbert TW*, Gilbert S, Madden M, Reynolds SD, Badylak SF†.

Hydrated versus lyophilized forms of porcine extracellular matrix derived from the urinary bladder.


Journal of Biomedical Materials Research. Part A. 2008;87:862-872. Freytes DO, Tullius RS, Valentin JE, Stewart-Akers AM, Badylak SF†.

Uniaxial and biaxial properties of terminally sterilized porcine urinary bladder matrix scaffolds.


Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 2008;84:408-414. Freytes DO, Stoner RM, Badylak SF†.

Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix.


Biomaterials. 2008;29:1630-1637. Freytes DO, Martin J, Velankar SS, Lee AS, Badylak SF†.

Immune response to biologic scaffold materials.


Seminars in immunology. 2008;20:109-116. Badylak SF†, Gilbert TW*.

Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular matrix scaffolds.


Tissue Engineering. 2007;13:2301-2310. Sellaro TL, Ravindra AK, Stolz DB, Badylak SF†.

Electromechanical characterization of a tissue-engineered myocardial patch derived from extracellular matrix.


The Journal of Thoracic and Cardiovascular Surgery. 2007;133:979-985. Ota T, Gilbert TW*, Badylak SF†, Schwartzman D, Zenati MA.

Tunica repair with acellular bladder matrix maintains corporal tissue function.


International Journal of Impotence Research. 2007;19:602-609. Eberli D, Susaeta R, Yoo JJ, Atala A†.

Reinforcement of esophageal anastomoses with an extracellular matrix scaffold in a canine model.


The Annals of Thoracic Surgery. 2006;82:2050-2058. Nieponice A†, Gilbert TW*, Badylak SF†.

The application of tissue engineering procedures to repair the larynx.


Journal of Speech, Language, and Hearing Research. 2006;49:194-208. Ringel RL, Kahane JC, Hillsamer PJ, Lee AS, Badylak SF†.

Decellularization of tissues and organs.


Biomaterials. 2006;27:3675-3683. Gilbert TW*, Sellaro TL, Badylak SF†.

Effect of storage upon material properties of lyophilized porcine extracellular matrix derived from the urinary bladder.


Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 2006;78:327-333. Freytes DO, Tullius RS*, Badylak SF†.

The basement membrane component of biologic scaffolds derived from extracellular matrix.


Tissue Engineering. 2006;12:519-526. Brown B, Lindberg K, Reing J, Stolz DB, Badylak SF†.

Antibacterial activity within degradation products of biological scaffolds composed of extracellular matrix.


Tissue Engineering. 2006;12:2949-2955. Brennan EP, Reing J, Chew D, Myers-Irvin JM, Young EJ, Badylak SF†.

The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium.


Cell Transplantation. 2006;15 Suppl 1:S29-40. Badylak SF†, Kochupura PV, Cohen IS, Doronin SV, Saltman AE, Gilbert TW*, Kelly DJ, Ignotz RA, Gaudette GR.

Use of a particulate extracellular matrix bioscaffold for treatment of acquired urinary incontinence in dogs.


Journal of the American Veterinary Medical Association. 2005;226:1095-1097. Wood JD†, Simmons-Byrd A, Spievack AR, Badylak SF†.

Extracellular matrix scaffold for cardiac repair.


Circulation. 2005;112:I135-143. Robinson KA, Li J, Mathison M, Redkar A, Cui J, Chronos NA, Matheny RG, Badylak SF†.

Production and characterization of ECM powder: Implications for tissue engineering applications.


Biomaterials. 2005;26:1431-1435. Gilbert TW*, Stolz DB, Biancaniello F, Simmons-Byrd A, Badylak SF†.

Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test.


Biomaterials. 2005;26:5518-5531. Freytes DO, Rundell AE, Vande Geest J, Vorp DA, Webster TJ, Badylak SF†.

Esophageal reconstruction with ECM and muscle tissue in a dog model.


The Journal of Surgical Research. 2005;128:87-97. Badylak SF†, Vorp DA, Spievack AR, Simmons-Byrd A, Hanke J, Freytes DO, Thapa A, Gilbert TW*, Nieponice A†.

Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function.


Circulation, 2005 - Am Heart Assoc. Kochupura PV, Azeloglu EU, Kelly DJ, Doronin SV, Badylak SF, Krukenkamp IB, Cohen IS, Gaudette GR.

Biaxial strength of multilaminated extracellular matrix scaffolds.


Biomaterials. 2004;25:2353-2361. Freytes DO, Badylak SF†, Webster TJ, Geddes LA, Rundell AE.

Extracellular matrix as a scaffold for laryngeal reconstruction.


The Annals of Otology, Rhinology, and Laryngology. 2003;112:428-433. Huber JE, Spievack A, Simmons-Byrd A, Ringel RL, Badylak S†.

Extracellular matrix for myocardial repair.


The Heart Surgery Forum. 2003;6:E20-26. Badylak S†, Obermiller J, Geddes L, Matheny R.

Retention of endothelial cell adherence to porcine-derived extracellular matrix after disinfection and sterilization.


Tissue Engineering. 2002;8:225-234++=+ Hodde JP, Record RD, Tullius RS*, Badylak SF†.

† Consultant

‡ ACell Sponsored Research Agreement

* ACell Employee