PUBLICATIONS


Scientific Validation

Urinary Bladder Matrix (UBM) has been researched extensively and its characteristics have been shown to be beneficial for various wound and surgical applications.

  • Trauma & reconstructive surgery

  • Abdominal wall repair

  • Urology

  • Advanced wound care


The following is a non-exhaustive list of published and peer-reviewed scientific articles involving Urinary Bladder Matrix (UBM). This information is for educational purposes only.

Clinical Studies

Long-term clinical, radiological, and histological follow-up after complex ventral incisional hernia repair using urinary bladder matrix graft reinforcement: a retrospective cohort study.


Hernia. 2018; doi: 10.1007/s10029-018-1830-0. Sasse KC†, Lambin JH, Gevorkian J, Elliott C, Afshar R, Gardner A, Mehta A, Lambin R, Peraza L.

Paraesophageal hiatal hernia repair with urinary bBladder matrix graft.


Journal of the Society of Laparoendoscopic Surgeons. 2018; 22(2). doi: 10.4293/JSLS.2017.00100. Howell RS, Fazzari M, Petrone P, Barkan A, Hall K, Servide MJ, Anduaga MF, Brathwaite CEM†.

Urinary bladder matrix reinforcement for laparoscopic hiatal hernia repair.


Journal of the Society of Laparoendoscopic Surgeons. 2018; 22(2). doi: 10.4293/ JSLS.2017.00060. Zografakis J†, Johnston G, Haas J, Berbiglia L, Bedford T, Spear J, Dan A, Pozsgay M.

Extracellular matrix applications in the treatment of open fractures with complex wounds and large soft tissue defects.


Journal of Orthopaedic Trauma. 2018; 32: e76-e80. Fokin AA, Puente I, Hus N†, Rodriguez E, Weisz RD.

Massive localized lymphedema: Wound reconstruction with extracellular matrix.


Wounds. 2017; 29(4): E22-E27. Scantling D, Pontell ME, Pedevillano L, Jacob TC, Guilday R.

Regenerative medicine for soft tissue coverage of the hand and upper extremity.


Current Orthopaedic Practice. 2017; 29(2): 120-126. Lanier ST, Ruter DI, Valerio IL.

Complicated mammoplasty and breast salvage with application of extracellular matrix.


American Surgeon. 2017; 83:E243-E244. Swickard AL, Sciarretta JD.

Porcine urinary bladder matrix for management of infected radiation mastectomy wound.


Cureus. 2017; 9(7): e1451. DOI 10.7759/cureus.1451. Puckett Y, Pham T, McReynolds S, Ronaghan CA†.

Laparoscopic rectopexy with urinary bladder xenograft reinforcement.


Journal of the Society of Laparoendoscopic Surgeons. 2017; 21(1): doi: 10.4293/JSLS.2016.00106. Mehta A, Afshar R, Warner DL, Gardner A, Ackerman E, Brandt J, Sasse KC†.

The use of acellular urinary bladder matrix as coverage for fasciocutaneous free flap donor sites: An alternative to traditional grafting procedures.


Journal of Oral Maxillofacial Surgery. 2017; doi: 10.1016/j.joms.2017.03.011. Melville JC, Bennetts NA, Tijerina L, Shum JW.

Diabetic foot ulcers treated with porcine urinary bladder extracellular matrix and total contact cast: Interim analysis of a randomized,
controlled trial.


Wounds. 2017; pii: WNDS20170227-1. Alvarez OM, Smith T, Gilbert TW*, Onumah NJ, Wendelken ME, Parker R, Markowitz L.

Management of open lower extremity wounds with concomitant fracture using a porcine urinary bladder matrix.


Wounds. 2016; 28(11): 342-349. Kraemer BA†, Geiger SE, Deigni OA, Watson JT.

A comparative analysis of skin substitutes used in the management of diabetic foot ulcers.


Journal of Wound Care; 25(Sup10):S8-S17. Martinson M, Martinson N.

Management of open distal lower extremity wounds with exposed tendons using porcine urinary bladder matrix.


Wounds. 2016; 28(9): 306-316. Geiger SE, Deigni OA, Watson JT, Kraemer BA†.

An evaluation of tissue engineering approaches for management of neuropathic diabetic foot ulcers resistant to standard of care: An interim analysis.


Journal of Wound Care. 2016; 25(Sup7):S18-S25. Frykberg RG, Cazzell SM, Arroyo-Rivera J, Tallis A, Reyzelmen AM, Saba F, Warren L, Stouch BC, Gilbert TW*.

New innovations for deep partial-thickness burn treatment with ACell MatriStem Matrix.


Advances in Wound Care. 2016; doi: 10.1089/wound.2015.0681. Kim JS, Kaminsky AJ, Summitt JB‡, Thayer WP‡.

Use of scaffolding tissue biografts To bolster vesicourethral anastomosis during salvage robot-assisted prostatectomy reduces leak rates and catheter times.


European Urology. 2016; doi: 10.1016/ j.eururo.2016.10.004. Ogaya-Pines G, Kadakia Y, Palayapalayam-Ganapathi H, Woodlief T, Jensen C, Syed J, Patal V.

Hiatal hernia repair with novel biological graft reinforcement.


Journal of the Society of Laparoendoscopic Surgeons. 2016; 20(2): doi: 10.4293/JSLS.2016.00016. Sasse KC†, Warner DL, Ackerman E, Brandt J.

Parastomal hernia repair with urinary bladder matrix grafts: Case series with 2-year follow-up and discussion.


International Journal of Case Reports and Images (IJCRI). 2016; 7(2):85-91. Sasse KC†, Warner DL, Ackerman E, Brandt J.

Extracellular matrix scaffold in diaphragmatic crura reinforcement during laparoscopic repair of large hiatal hernia.


Journal of Surgery & Transplantation Science. 2016; 4(1): 1018-21. Reznichenko AA.

Different biologic grafts for diaphragmatic crura reinforcement during laparoscopic repair of large hiatal hernia: A 6-Year single surgeon experience.


Journal of Medical Implants and Surgery. 2015; 1:101. doi:10.4172/jmis.1000101. Reznichenko AA.

Acellular micronized extracellular matrix and occlusive dressings for open fingertip injuries.


Plastic and Aesthetic Research. 2015; 2:282-3. Dreifuss SE, Wollstein R, Badylak SF†, Rubin PJ.

The use of urinary bladder matrix in the treatment of trauma and combat casualty wound care.


Regenerative Medicine. 2015; 10(5):611-622. Valerio IL, Campbell P, Sabino J, Dearth CD, Fleming M.

Report of an unusually large, surgically excised squamous cell carcinoma successfully treated with porcine transitional epithelium.


Journal of the American Academy of Dermatology. 2015; 1:200-2. Bacigalupi R, Khorasani H.

Endoscopic deployment of MatriStem for treatment of a colorectal anastomotic leak.


Case Reports from Society of Laparoendscopic Surgeons. 2015; doi: 10.4293/CRSLS.2014.00080. Iorio T, Blumberg.

Esophageal Reinforcement with a Extracellular Scaffold During Total Gastrectomy for Gastric Cancer.


Annals of Surgical Oncology. 2014; doi:10.1245/s10434-014-4125-4. Afaneh C, Abelson J, Schattner M, Janjigian YY, Ilson D, Yoon SS, Strong VE.

The use of urinary bladder matrix in the treatment of complicated open wounds.


Wounds. 2014; 26(7):189-196. Parcells AL, Abernathie B, Ramazi D.

Application of the orthoplastic reconstructive ladder to preserve lower extremity amputation length.


Annals of Plastic Surgery. 2014. Fleming ME, O'Daniel A, Bharmal H, Valerio I.a

Regenerative medicine applications in combat casualty care.


Regenerative Medicine. 2014;9:179-190. Fleming ME, Bharmal H, Valerio I.

Accelerated healing of complex open pilonidal wounds using matristem extracellular matrix xenograft: Nine cases.


Journal of Surgical Case Reports. 2013;4. Sasse KC†, Brandt J, Lim DC, Ackerman E.

Complex wounds treated with matristem xenograft material: Case series and cost analysis.


OA Surgery. 2013;1. Sasse KC†, Ackerman EM, Brandt JR.

Urinary bladder matrix for the treatment of recalcitrant nonhealing radiation wounds.


Advances in Skin & Wound Care. 2013;26:450-455. Rommer EA, Peric M, Wong A.

Salvage of failed local and regional flaps with porcine urinary bladder extracellular matrix aided tissue regeneration.


Case Reports in Otolaryngology. 2013;2013:917183. Kruper GJ, Vandegriend ZP, Lin HS, Zuliani GF.

Porcine bladder extracellular matrix for closure of a large defect in a burn contracture release.


Journal of Wound Care. 2012;21:454-456. Mitchell KB, Gallagher JJ.

Porcine urinary bladder matrix: A retrospective study and establishment of protocol.


Journal of Wound Care. 2012;21:476, 478-480, 482. Lecheminant J, Field C.

Nasal resurfacing with xenographic bladder bioscaffold following excision of massive rhinophyma.


Journal of Otology and Rhinology. 2012;1:3, 1-3. Vande Griend ZP, Zuliani GF.

The clinical effectiveness in wound healing with extracellular matrix derived from porcine urinary bladder matrix: A case series on severe chronic wounds.


The Journal of the American College of Certified Wound Specialists. 2010;2:55-59. Kimmel H, Rahn M, Gilbert TW*.

Pre-Clinical Studies

Comparison of in vivo remodeling of urinary bladder matrix and acellular dermal matrix in an ovine model.


Regenerative Medicine. 2018; doi: 10.2217/rme-2018-0091. Young DA*, McGilvray KC, Ehrhart N Gilbert TW*.

Retrorectus repair of incisional ventral hernia with urinary bladder matrix reinforcement in a long-term porcine model.


Regenerative Medicine. 2018; doi:10.2217/rme-2018-0023. Young DA*, Jackson N, Ronaghan CA†, Brathwaite CEM†, Gilbert TW*.

Proteomic composition and immunomodulatory properties of urinary bladder matrix scaffolds in homeostatis and injury.


Seminars in Immunology. 2017; http://dx.doi.org/ 10.1016/j.smim.2017.05.002. Sadtler K, Sommerfeld SD, Wolf MT, Wang X, Majumdar S, Chung L, Kelkar DS, Pandley A, Elisseeff JH‡.

Mechanical strength vs. degradation of a biologically-derived surgical mesh over time in a rodent full thickness abdominal wall defect.


Biomaterials. 2016; 108:81-90. Costa A, Naranjo JD, Turner NJ, Swinehart IT, Kolich BD, Shaffiey SA, Londono R, Keane TJ, Reing JE, Johnson SA, Badylak SF†.

Solubilized extracellular matrix bioscaffolds derived from diverse source tissues differentially influence macrophage phenotype.


Journal of Biomedical Materials Research A. 2016; doi: 10.1002/jbm.a.35894. Dziki JL, Wang DS, Pineda C, Sicari BM, Rausch T, Badylak SF†.

Urinary bladder matrix scaffolds strengthen esophageal hiatus repair.


Journal of Surgical Research. 2016; 204:344-50. Riganti JM, Ciotola F, Amenabar A, Craiem D, Graf S, Badaloni A, Gilbert TW*, Nieponice A‡.

Inhibition of COX1/2 alters the host response and reduces ECM scaffold mediated constructive tissue remodeling in a rodent model of skeletal muscle injury.


Acta Biomaterialia. 2015. http://dx.doi.org/10.1016/j.actbio.2015.11.043. Dearth CL, Slivka PF, Steward SA, Keane TJ, Tay JK, Londono R, Goh Q, Pizza FX, Badylak SF.

In vitro evaluation of acellular porcine urinary bladder extracellular matrix – A potential scaffold in tissue engineered skin.


Wound Medicine. 2015;10-11:9-16. Coakley DN, Shaikh FM, O’Sullivan K, Kavanagh EG, Grace PA, McGloughlin TM.

Fractionation of an ECM hydrogel into structural and soluble components reveals distinctive roles in regulating macrophage behavior.


Biomaterials Science. 2014; 2(10):1521-34. Slivka PF, Dearth CL, Keane TJ, Meng FW, Medberry CJ, Riggio RT, Reing JE, Badylak SF†.

The effect of detergents on the basement membrane complex of a biologic scaffold material.


Acta Biomaterialia. 2014;10:183-193. Faulk DM, Carruthers CA, Warner HJ, Kramer CR, Reing JE, Zhang L, D'Amore A, Badylak SF†.

Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials.


Acta Biomaterialia. 2012;8:978-987. Brown BN, Londono R, Tottey S, Zhang L, Kukla KA, Wolf MT, Daly KA, Reing JE, Badylak SF†.

One and four layer acellular bladder matrix for fascial tissue reconstruction.


Journal of Materials Science. Materials in Medicine. 2011;22:741-751. Eberli D, Atala A†, Yoo JJ.

The surface molecular functionality of decellularized extracellular matrices.


Biomaterials. 2011;32:137-143. Barnes CA, Brison J, Michel R, Brown BN, Castner DG, Badylak SF†, Ratner BD.

Surface characterization of extracellular matrix scaffolds.


Biomaterials. 2010;31:428-437. Brown BN, Barnes CA, Kasick RT, Michel R, Gilbert TW*, Beer-Stolz D, Castner DG, Ratner BD, Badylak SF†.

Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component.


Biomaterials. 2009;30:1482-1491. Brown BN, Valentin JE, Stewart-Akers AM, McCabe GP, Badylak SF†.

Extracellular matrix as a biological scaffold material: Structure and function.


Acta Biomaterialia. 2009;5:1-13. Badylak SF†, Freytes DO, Gilbert TW*.

Quantification of DNA in biologic scaffold materials.


Journal of Surgical Research. 2009; 152: 135-139. Gilbert TW*, Freund JM, Badylak SF†.

Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrix.


Biomaterials. 2008;29:4775-4782. Gilbert TW*, Wognum S, Joyce EM, Freytes DO, Sacks MS, Badylak SF†.

Hydrated versus lyophilized forms of porcine extracellular matrix derived from the urinary bladder.


Journal of Biomedical Materials Research. Part A. 2008;87:862-872. Freytes DO, Tullius RS, Valentin JE, Stewart-Akers AM, Badylak SF†.

Uniaxial and biaxial properties of terminally sterilized porcine urinary bladder matrix scaffolds.


Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 2008;84:408-414. Freytes DO, Stoner RM, Badylak SF†.

Reinforcement of esophageal anastomoses with an extracellular matrix scaffold in a canine model.


The Annals of Thoracic Surgery. 2006;82:2050-2058. Nieponice A†, Gilbert TW*, Badylak SF†.

Decellularization of tissues and organs.


Biomaterials. 2006;27:3675-3683. Gilbert TW*, Sellaro TL, Badylak SF†.

Effect of storage upon material properties of lyophilized porcine extracellular matrix derived from the urinary bladder.


Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 2006;78:327-333. Freytes DO, Tullius RS*, Badylak SF†.

The basement membrane component of biologic scaffolds derived from extracellular matrix.


Tissue Engineering. 2006;12:519-526. Brown B, Lindberg K, Reing J, Stolz DB, Badylak SF†.

Production and characterization of ECM powder: Implications for tissue engineering applications.


Biomaterials. 2005;26:1431-1435. Gilbert TW*, Stolz DB, Biancaniello F, Simmons-Byrd A, Badylak SF†.

Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test.


Biomaterials. 2005;26:5518-5531. Freytes DO, Rundell AE, Vande Geest J, Vorp DA, Webster TJ, Badylak SF†.

Biaxial strength of multilaminated extracellular matrix scaffolds.


Biomaterials. 2004;25:2353-2361. Freytes DO, Badylak SF†, Webster TJ, Geddes LA, Rundell AE.

Retention of endothelial cell adherence to porcine-derived extracellular matrix after disinfection and sterilization.


Tissue Engineering. 2002;8:225-234++=+ Hodde JP, Record RD, Tullius RS*, Badylak SF†.

† Consultant

‡ ACell Sponsored Research Agreement

* ACell Employee