Technology


ACell’s patented core technology is the only commercially available form of Urinary Bladder Matrix (UBM). UBM appears to facilitate the body’s naturally adaptive or accommodative immune response, which is conducive for wound healing and three-dimensional growth of various cell types.1 In the presence of UBM, in pre-clinical studies, the body has been observed to:

  • Demonstrate an anti-inflammatory response 2
  • Completely resorb and incorporate the material 2,3
  • Mobilize site-appropriate and progenitor cells 2,4,5
  • Promote the formation of site-specific tissue through constructive remodeling 2,3,6,7


  1. 1 Brown B, Lindberg K, Reing J, et al. The basement membrane component of biologic scaffolds derived from extracellular matrix. Tissue Eng. 2006 Mar; 12(3):519-26. Growth factor and GAG data on file.
  2. Brown BN, Londono R, Tottey S, et al. Acta Biomater. 2012 Mar;8(3):978-87.
  3. Gilbert TW, Nieponice A, Spievack AR, et al. Repair of the thoracic wall with an extracellular matrix scaffold in a canine model. J Surg Res. 2008 Jun; 147(1):61-7.
  4. Reing JE, Zhang L, Myers-Irvin J, et al. Degradation products of extracellular matrix affect cell migration and proliferation. Tissue Eng Part A. 2009 Mar;15(3):605-14.
  5. Agrawal V, Johnson SA, Reing J, et al. Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci USA. 2010 Feb; 107(8):3351-5.
  6. Nieponice A, Gilbert TW, Badylak SF. Reinforcement of esophageal anastomoses with an extracellular matrix scaffold in a canine model. Ann Thorac Surg. 2006 Dec; 82(6):2050-8.
  7. Boruch AV, Nieponice A, Qureshi IR, et al. Constructive remodeling of biologic scaffolds is dependent on early exposure to physiologic bladder filling in a canine partial cystectomy model. J Surg Res. 2010 Jun 15;161(2):217-25.