Scientific Discovery that Led to the Founding of ACell
Our core platform urinary bladder matrix (UBM) technology is based on the influential work of our founder, the late Dr. Alan Spievack. Dr. Spievack’s research on extracellular matrix (ECM) constructs comprised of the epithelial basement membrane of the mammalian urinary bladder led to the invention of our UBM technology platform and the founding of ACell in 1999.
Inspired by salamanders that can grow back limbs, Dr. Spievack began working in cell regeneration in the 1950s and through his research he discovered a special characteristic of the basement membrane: remove it and a salamander’s limb would not regenerate. The basement membrane – a thin sheet of fibers that underlies the epithelium tissue of a cell and exists in every living cell in our bodies – was somehow responsible for constructive remodeling of tissue.