MatriStem Devices

Advantages of MatriStem®

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ACell’s MatriStem products are the only commercially available extracellular matrix (ECM) made of urinary bladder matrix (UBM).

The primary advantage of MatriStem products is that they maintain their natural collagen structure and components that are gradually incorporated within the patients’ body while replacing the product with site-appropriate tissue. The wound undergoes a remodeling process where scarring would be expected, thereby restoring natural site-appropriate tissue to the site of injury.

Expect More With MatriStem

We take pride that MatriStem is a solution that medical professionals turn to when treating some of the toughest wound and surgical soft tissue repair cases. To date, MatriStem has been used to help over 75,000 patients.

Novel Characteristics of MatriStem® Products

MatriStem facilitates the body’s own regenerative capabilities and helps restore normal site-appropriate tissue, offering novel healing characteristics that we believe address the limitations of existing regenerative medicine products.

  • Composition: MatriStem contains a collection of collagens, carbohydrates and proteins arranged in a complex, three-dimensional arrangement of ECM components.
  • Characteristics: MatriStem has two distinct surfaces, each with beneficial characteristics. Together, the two surfaces facilitate tissue remodeling and contribute to the prevention of scar tissue formation during the healing process.
    • The basement membrane surface is a thin extracellular matrix structure that serves as a barrier between the epithelium and other tissues. Studies have shown that the presence of an epithelial basement membrane is critical to the reparative capacity of many organs. It is an ideal substrate for epithelial and progenitor cell attachment and proliferation.
    • The lamina propria surface, a more open, collagenous structure that is conducive for integration into the wound bed and host connective tissues.
  • Development: MatriStem is derived from naturally-occurring porcine urinary bladder that is carefully treated to remove cellular debris without the use of harsh detergents or chemicals, resulting in a material that is acellular, non-crosslinked and resorbable.
    • Acellular: Acellular tissue is preferable in wound care and surgical procedures because it aides in maximizing the beneficial effects of the ECM while minimizing the adverse immune response associated with cellular debris. ACell accomplishes the removal of cellular debris from MatriStem Products without the potential for residual detergents to be retained within the resulting scaffold.
    • Non-Crosslinked: ACell’s material processing techniques remove the need for artificial crosslinking, which can denature a tissue graft, interfere with the body’s ability to resorb the graft, and is much more likely to lead to scarring and calcification rather than native tissue remodeling. As a result, non-crosslinked MatriStem serves as a resorbable matrix and receptor site of new cell formation.
    • Resorbable: MatriStem degrades over time through the body’s natural enzymatic processes as the scaffold is replaced with site-appropriate tissue growth. During the degradation process, MatriStem facilitates the body’s own cells to populate the area and assimilate as part of the natural remodeling process.


Overview of Indications

MatriStem devices can be used in a broad range of wound care procedures and surgical repairs.

  • Complex wound management: MatriStem products are intended for the management of wounds including diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), pressure ulcers and second degree burns
  • Surgical soft tissue repair: MatriStem products are intended for implantation to reinforce soft tissue where weakness exists in urological, gynecological and gastrointestinal anatomy

Learn more about current indications of MatriStem devices here  and future opportunities using MatriStem devices here.


Manufacturing

Currently, the Company produces MatriStem devices at state-of-the-art manufacturing facilities in Lafayette, Indiana and in Columbia, Maryland and has initiated expansion plans at both facilities. MatriStem products are manufactured from readily available porcine bladders in a proprietary manufacturing process involving minimal chemical treatment. The process is both complex and highly specialized, requiring precision and expertise to address various technical, engineering and regulatory challenges.